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Acute graft versus host disease

MedGen UID:
208987
•Concept ID:
C0856825
•
Disease or Syndrome
Synonym: Acute graft vs. host disease
SNOMED CT: Acute graft-versus-host disease (402355000); Acute graft versus host disease (402355000)
 
Monarch Initiative: MONDO:0020546
Orphanet: ORPHA99920

Definition

A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and GI tract. The onset is usually within one hundred days of transplantation or immunologic manipulation. [from NCI]

Professional guidelines

PubMed

Novel developments in the prophylaxis and treatment of acute GVHD.
Jamy O, Zeiser R, Chen YB
Blood 2023 Sep 21;142(12):1037-1046. doi: 10.1182/blood.2023020073. PMID: 37471585
Allogeneic, donor-derived, second-generation, CD19-directed CAR-T cells for the treatment of pediatric relapsed/refractory BCP-ALL.
Del Bufalo F, Becilli M, Rosignoli C, De Angelis B, Algeri M, Hanssens L, Gunetti M, Iacovelli S, Li Pira G, Girolami E, Leone G, Lazzaro S, Bertaina V, Sinibaldi M, Di Cecca S, Iaffaldano L, Künkele A, Boccieri E, Del Baldo G, Pagliara D, Merli P, Carta R, Quintarelli C, Locatelli F
Blood 2023 Jul 13;142(2):146-157. doi: 10.1182/blood.2023020023. PMID: 37172203
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article

Recent clinical studies

Etiology

Ruxolitinib versus basiliximab for steroid-refractory acute graft-versus-host disease: a retrospective study.
Liu J, Fan Z, Xu N, Ye J, Chen Y, Shao R, Sun Y, Wu Q, Liu Q, Jin H
Ann Hematol 2023 Oct;102(10):2865-2877. Epub 2023 Jul 20 doi: 10.1007/s00277-023-05361-9. PMID: 37474631
Acute Graft-versus-Host Disease: An Update on New Treatment Options.
Patel DA, Crain M, Pusic I, Schroeder MA
Drugs 2023 Jul;83(10):893-907. Epub 2023 May 29 doi: 10.1007/s40265-023-01889-2. PMID: 37247105
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype.
Su Y, Sun X, Liu X, Qu Q, Yang L, Chen Q, Liu F, Li Y, Wang Q, Huang B, Huang XJ, Zhang XH
J Hematol Oncol 2022 Jul 21;15(1):99. doi: 10.1186/s13045-022-01315-2. PMID: 35864538Free PMC Article
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Cytokines and costimulation in acute graft-versus-host disease.
Hill GR, Koyama M
Blood 2020 Jul 23;136(4):418-428. doi: 10.1182/blood.2019000952. PMID: 32526028Free PMC Article

Diagnosis

Diagnostic and prognostic role of elafin in skin acute graft versus host disease: a systematic review.
Bhattarai A, Shah S, Yadav R, Dhakal G, Neupane R, Paudel S, Bhandari P, Abu Serhan H, Sah R, Sah S, Barboza JJ
Hematology 2024 Dec;29(1):2293497. Epub 2023 Dec 19 doi: 10.1080/16078454.2023.2293497. PMID: 38112182
Data-driven grading of acute graft-versus-host disease.
Bayraktar E, Graf T, Ayuk FA, Beutel G, Penack O, Luft T, Brueder N, Castellani G, Reinhardt HC, Kröger N, Beelen DW, Turki AT
Nat Commun 2023 Nov 28;14(1):7799. doi: 10.1038/s41467-023-43372-2. PMID: 38017035Free PMC Article
Acute graft-versus-host disease.
Malard F, Holler E, Sandmaier BM, Huang H, Mohty M
Nat Rev Dis Primers 2023 Jun 8;9(1):27. doi: 10.1038/s41572-023-00438-1. PMID: 37291149
Acute Graft-Versus-Host Disease: A Brief Review.
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article
Acute graft-versus-host disease of the gut: considerations for the gastroenterologist.
Naymagon S, Naymagon L, Wong SY, Ko HM, Renteria A, Levine J, Colombel JF, Ferrara J
Nat Rev Gastroenterol Hepatol 2017 Dec;14(12):711-726. Epub 2017 Sep 27 doi: 10.1038/nrgastro.2017.126. PMID: 28951581Free PMC Article

Therapy

A randomized phase 2 trial of oral vitamin A for graft-versus-host disease in children and young adults.
Khandelwal P, Langenberg L, Luebbering N, Lake KE, Butcher A, Bota K, Ramos KN, Taggart C, Choe H, Vasu S, Teusink-Cross A, Koo J, Wallace G, Romick-Rosendale L, Watanabe-Chailland M, Haslam DB, Lane A, Davies SM
Blood 2024 Mar 21;143(12):1181-1192. doi: 10.1182/blood.2023022865. PMID: 38227933
Novel developments in the prophylaxis and treatment of acute GVHD.
Jamy O, Zeiser R, Chen YB
Blood 2023 Sep 21;142(12):1037-1046. doi: 10.1182/blood.2023020073. PMID: 37471585
Acute graft-versus-host disease.
Malard F, Holler E, Sandmaier BM, Huang H, Mohty M
Nat Rev Dis Primers 2023 Jun 8;9(1):27. doi: 10.1038/s41572-023-00438-1. PMID: 37291149
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.
Zeiser R, von Bubnoff N, Butler J, Mohty M, Niederwieser D, Or R, Szer J, Wagner EM, Zuckerman T, Mahuzier B, Xu J, Wilke C, Gandhi KK, Socié G; REACH2 Trial Group
N Engl J Med 2020 May 7;382(19):1800-1810. Epub 2020 Apr 22 doi: 10.1056/NEJMoa1917635. PMID: 32320566

Prognosis

Innovations in treating acute graft-versus-host disease: a review of preclinical targets and strategies.
Duan H, Ru Y, Chen J
Expert Opin Ther Targets 2024 Sep;28(9):807-824. Epub 2024 Sep 19 doi: 10.1080/14728222.2024.2405091. PMID: 39300696
Outcomes in Critically Ill Allogeneic Hematopoietic Stem-Cell Transplantation Recipients.
Lafarge A, Dupont T, Canet E, Moreau AS, Picard M, Mokart D, Platon L, Mayaux J, Wallet F, Issa N, Raphalen JH, Pène F, Renault A, Peffault de la Tour R, Récher C, Chevallier P, Zafrani L, Darmon M, Bigé N, Azoulay E
Am J Respir Crit Care Med 2024 Oct 15;210(8):1017-1024. doi: 10.1164/rccm.202401-0135OC. PMID: 39018219
Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD.
Akahoshi Y, Spyrou N, Hogan WJ, Ayuk F, DeFilipp Z, Weber D, Choe HK, Hexner EO, Rösler W, Etra AM, Sandhu K, Yanik GA, Chanswangphuwana C, Kitko CL, Reshef R, Kraus S, Wölfl M, Eder M, Bertrand H, Qayed M, Merli P, Grupp SA, Aguayo-Hiraldo P, Schechter T, Ullrich E, Baez J, Beheshti R, Gleich S, Kowalyk S, Morales G, Young R, Kwon D, Nakamura R, Levine JE, Ferrara JLM, Chen YB
Blood Adv 2023 Aug 22;7(16):4479-4491. doi: 10.1182/bloodadvances.2023009885. PMID: 37315175Free PMC Article
Graft-versus-host disease management.
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540
Effect of HLA mismatch on acute graft-versus-host disease.
Kanda J
Int J Hematol 2013 Sep;98(3):300-8. Epub 2013 Jul 28 doi: 10.1007/s12185-013-1405-x. PMID: 23893313

Clinical prediction guides

Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease.
Lin Y, Gu Q, Lu S, Pan Z, Yang Z, Li Y, Yang S, Lv Y, Zheng Z, Sun G, Gou F, Xu C, Zhao X, Wang F, Wang C, Yuan S, Xie X, Cao Y, Liu Y, Gu W, Cheng T, Cheng H, Hu X
J Clin Invest 2023 Aug 1;133(15) doi: 10.1172/JCI162201. PMID: 37338986Free PMC Article
Acute Graft-versus-Host Disease: An Update on New Treatment Options.
Patel DA, Crain M, Pusic I, Schroeder MA
Drugs 2023 Jul;83(10):893-907. Epub 2023 May 29 doi: 10.1007/s40265-023-01889-2. PMID: 37247105
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype.
Su Y, Sun X, Liu X, Qu Q, Yang L, Chen Q, Liu F, Li Y, Wang Q, Huang B, Huang XJ, Zhang XH
J Hematol Oncol 2022 Jul 21;15(1):99. doi: 10.1186/s13045-022-01315-2. PMID: 35864538Free PMC Article
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
MAGIC biomarkers of acute graft-versus-host disease: Biology and clinical application.
Srinagesh HK, Ferrara JLM
Best Pract Res Clin Haematol 2019 Dec;32(4):101111. Epub 2019 Oct 18 doi: 10.1016/j.beha.2019.101111. PMID: 31779977Free PMC Article

Recent systematic reviews

Diagnostic and prognostic role of elafin in skin acute graft versus host disease: a systematic review.
Bhattarai A, Shah S, Yadav R, Dhakal G, Neupane R, Paudel S, Bhandari P, Abu Serhan H, Sah R, Sah S, Barboza JJ
Hematology 2024 Dec;29(1):2293497. Epub 2023 Dec 19 doi: 10.1080/16078454.2023.2293497. PMID: 38112182
Vedolizumab for acute gastrointestinal graft-versus-host disease: A systematic review and meta-analysis.
Li AC, Dong C, Tay ST, Ananthakrishnan A, Ma KS
Front Immunol 2022;13:1025350. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1025350. PMID: 36439135Free PMC Article
Efficacy and safety of ruxolitinib in steroid-refractory graft-versus-host disease: A meta-analysis.
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Beyond steroids: A systematic review and proposed solutions to managing acute graft-versus-host disease in adolescents and young adults.
Friend BD, Schiller GJ
Blood Rev 2022 Mar;52:100886. Epub 2021 Sep 2 doi: 10.1016/j.blre.2021.100886. PMID: 34509319
Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis.
Hashmi S, Ahmed M, Murad MH, Litzow MR, Adams RH, Ball LM, Prasad VK, Kebriaei P, Ringden O
Lancet Haematol 2016 Jan;3(1):e45-52. Epub 2015 Nov 27 doi: 10.1016/S2352-3026(15)00224-0. PMID: 26765648

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